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Transiciones de fase tisular en el desarrollo: más que simple mecánica
Laura Rustarazo-Calvo1,2, Karen Grace Soans1, Nicoletta I Petridou1
1European Molecular Biology Laboratory Heidelberg, Developmental Biology Unit, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
Development (Cambridge, England)
|February 12, 2026
Resumen
Las transiciones de fase tisular embrionaria, impulsadas por señales internas, dan forma activamente al desarrollo. Estas transiciones integran mecánica y señalización, asegurando una formación de patrones precisa y robusta desde el nivel molecular hasta el tisular.
Área de la Ciencia:
- Biología del desarrollo; Biofísica; Biología celular
Sus antecedentes:
- La morfogénesis tisular depende de patrones dinámicos de deformabilidad.
- Las transiciones de fase de materiales ocurren en cambios críticos en las propiedades celulares (parámetros de control).
- A diferencia de las transiciones pasivas en materia no viva, las transiciones tisulares son impulsadas activamente por señales biológicas internas.
Objetivo del estudio:
- Explorar los roles de las transiciones de fase tisular embrionaria en el desarrollo.
- Investigar el vínculo entre la mecánica tisular, la señalización mecanoquímica y la formación de patrones.
- Comprender cómo estas transiciones regulan el crecimiento y la especificación del destino celular.
Principales métodos:
- Revisión de la literatura existente sobre mecánica tisular y biología del desarrollo.
- Análisis de roles canónicos (centrados en la mecánica) y no canónicos (más allá de la mecánica).
- Integración de conceptos de la ciencia de materiales y la señalización del desarrollo.
Principales resultados:
- Las transiciones de fase tisular embrionaria regulan activamente la deformabilidad e integran los cambios mecánicos con las vías de señalización.
- Estas transiciones instruyen la formación de patrones espaciotemporales complejos, autoorganizados y adaptativos.
- Las transiciones de fase acoplan procesos a nivel molecular, celular y tisular para la precisión del desarrollo.
Conclusiones:
- Las transiciones de fase tisular embrionaria son una estrategia clave para el acoplamiento espaciotemporal en sistemas en desarrollo.
- Facilitan la robustez y precisión del desarrollo al integrar diversos procesos biológicos.
- Estas transiciones desempeñan roles cruciales en el control del crecimiento y la especificación del destino celular durante la embriogénesis.
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