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Cambios en la conectividad funcional del estado de reposo asociados con síntomas de estrés postraumático y ansiedad

Minjee Jung¹, Kyoung Jin Kim², Kyeong Jin Kim²

¹Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea.

Psychiatry investigation

|February 12, 2026

Resumen

Los refugiados norcoreanos (NKR) exhiben patrones de conectividad cerebral distintos en comparación con los controles sanos surcoreanos (SKC). Estas diferencias neurobiológicas están relacionadas con el trauma, el trastorno de estrés postraumático y la ansiedad, lo que pone de relieve los desafíos de salud mental en las RNC.

Área de la Ciencia:

La neurociencia es la neurociencia.
La psiquiatría es la psiquiatría.
Investigación en Salud Mental.

Sus antecedentes:

Los refugiados norcoreanos (NKR) experimentan un trauma significativo durante el escape y el reasentamiento.
Los desafíos de salud mental son frecuentes en las RNC, sin embargo, la investigación neurobiológica sigue siendo limitada.
Comprender los fundamentos neurobiológicos de la salud mental en las RNC es crucial para intervenciones efectivas.

Objetivo del estudio:

Investigar las diferencias en la conectividad funcional en estado de reposo (RSFC) entre los NKR y los controles sanos de Corea del Sur (SKC).
Explorar la asociación entre los síntomas psiquiátricos (PTSD, depresión, ansiedad) y la conectividad funcional (FC) en las RNC.

Principales métodos:

Se utilizó imágenes de resonancia magnética funcional (fMRI) para evaluar 28 NKR y 28 SKC coincidentes.
Los participantes fueron evaluados por trastorno de estrés postraumático (TEPT), depresión y ansiedad.
El análisis de FC de semilla a vocelo se realizó utilizando la caja de herramientas CONN.

Principales resultados:

Las NKR mostraron alteraciones significativas de RSFC en comparación con las SKC.
Las diferencias específicas incluyeron una conectividad alterada en regiones asociadas con el procesamiento emocional, el control cognitivo y la recompensa.
FC entre la amígdala derecha y la corteza visual correlacionado con la gravedad del TEPT, y la conectividad que involucra el estriado ventral y el cerebelo correlacionado con la ansiedad.

Conclusiones:

Se identificaron cambios distintos de RSFC en las NKR, diferenciándolas de las SKC.
Estos hallazgos sugieren posibles trastornos en el procesamiento emocional y de recompensa, el control cognitivo y la regulación de la ansiedad.
El estudio subraya el impacto neurobiológico del trauma y el reasentamiento en la salud mental de los NKR.

Palabras clave:

Ansiedad Ansiedad.Las imágenes de resonancia magnética.Refugiados norcoreanos refugiados norcoreanos.El trastorno de estrés postraumático es un trastorno de estrés postraumático.El trauma es el trauma.

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