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Updated: Feb 14, 2026

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Terapia de Captura Neutrónica con Boro: Un Renacimiento Impulsado por la Tecnología

Dandan Zheng1, Guang Han2, Olga Dona Maria Lemus3

  • 1Department of Radiation Oncology, University of Rochester, Rochester, NY 14627, USA.

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Resumen

La terapia de captura neutrónica con boro (BNCT) avanza rápidamente con nuevos fármacos de boro, fuentes de neutrones e imágenes. Esta radioterapia dirigida ofrece una nueva y prometedora opción para cánceres difíciles de tratar.

Palabras clave:
BNCTboroneutrónterapia personalizadamedicina de precisiónteranóstica

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Área de la Ciencia:

  • Oncología
  • Oncología de Radiación
  • Física Médica

Sus antecedentes:

  • La terapia de captura neutrónica con boro (BNCT) es una modalidad de radiación binaria dirigida.
  • Los primeros intentos de BNCT se vieron limitados por agentes de administración de boro y fuentes de neutrones inadecuados.
  • Los avances tecnológicos recientes han revitalizado la BNCT, haciéndola clínicamente viable.

Objetivo del estudio:

  • Revisar los avances recientes y el resurgimiento de la Terapia de Captura Neutrónica con Boro (BNCT).
  • Destacar las innovaciones tecnológicas clave que permiten la BNCT moderna.
  • Discutir las aplicaciones clínicas en expansión y el potencial futuro de la BNCT.

Principales métodos:

  • Revisión de los avances tecnológicos recientes en sistemas de administración de boro (compuestos, nanopartículas).
  • Análisis de los avances en fuentes de neutrones basadas en aceleradores y enfoques teranósticos (PET, RM).
  • Examen del modelado de biodistribución impulsado por IA para la planificación del tratamiento personalizado.

Principales resultados:

  • La BNCT utiliza ahora aceleradores compatibles con hospitales y sistemas de administración de boro de próxima generación.
  • La teranóstica avanzada y el modelado de IA apoyan la planificación del tratamiento personalizado y la selección de pacientes.
  • Las aprobaciones regulatorias y los programas clínicos se están expandiendo a nivel mundial, particularmente en Asia.

Conclusiones:

  • La BNCT ha pasado a ser una plataforma terapéutica con soporte comercial y un importante respaldo industrial.
  • Su naturaleza híbrida única combina la terapia dirigida con radiación de haz externo controlable.
  • La BNCT muestra promesa para diversas neoplasias difíciles y está posicionada para ser una modalidad transformadora en la oncología de precisión.