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Descifrando la lactilación en el dolor neuropático: patrones de infiltración de células inmunitarias y biomarcadores

Wenhui Wu¹, Denghao Yang²

¹Department of Anesthesiology, Hospital of Traditional Chinese Medicine of Emeishan City, Leshan, China.

|February 13, 2026

Resumen

Los investigadores identificaron los genes asociados a la lactilación CYP27A1 y PHKB como genes clave en el dolor neuropático (DN). Estos genes muestran potencial diagnóstico y se correlacionan con la infiltración de células inmunitarias, ofreciendo nuevas perspectivas sobre la patogénesis y el diagnóstico del DN.

Área de la Ciencia:

Bioquímica y Biología Molecular
Inmunología
Genética

Sus antecedentes:

La patogénesis del dolor neuropático (DN) aún no se comprende completamente.
La lactilación, una modificación postraduccional, está implicada en diversos procesos biológicos.
La identificación de nuevos biomarcadores para el DN es crucial para mejorar el diagnóstico y el tratamiento.

Objetivo del estudio:

Identificar genes asociados a la lactilación relacionados con la infiltración inmunitaria en el dolor neuropático.
Explorar el potencial diagnóstico de estos genes utilizando enfoques bioinformáticos y de aprendizaje automático.
Investigar la correlación entre los biomarcadores candidatos y la distribución de células inmunitarias en el DN.

Principales métodos:

Análisis integrado de conjuntos de datos de microarrays (GSE124272, GSE150408, GSE95849) de pacientes con DN y controles sanos.
Aplicación de algoritmos de aprendizaje automático (LASSO, SVM-RFE, Random Forest) para la identificación de firmas genéticas diagnósticas.
Análisis de enriquecimiento funcional (GO, KEGG) y análisis de infiltración inmunitaria.

Principales resultados:

Se identificaron cinco genes diagnósticos potenciales (CYP27A1, ELAC2, TMEM126B, LYRM7, PHKB).
CYP27A1 y PHKB se validaron como biomarcadores diagnósticos robustos en un conjunto de datos independiente.
Se observaron alteraciones significativas en 19 tipos de células inmunitarias, con CYP27A1 y PHKB correlacionándose con la distribución de células inmunitarias.

Conclusiones:

CYP27A1 y PHKB se identifican como biomarcadores potenciales asociados a la lactilación para el dolor neuropático.
Estos biomarcadores ofrecen información sobre la patogénesis del DN y la participación del sistema inmunitario.
Los hallazgos proporcionan una base teórica para mejorar las estrategias de diagnóstico del DN.

Palabras clave:

bioinformática biomarcadores diagnósticos lactilación aprendizaje automático dolor neuropático

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