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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
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Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
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Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
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Protocolo para cuantificar patrones de interacción entre alteraciones genómicas en el cáncer

Adrián Maqueda-Real1, Seokjin Ham1, Laia Ollé-Monràs2

  • 1Cancer Genomics Program, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain.

STAR protocols
|February 13, 2026
PubMed
Resumen
Este resumen es generado por máquina.

Este estudio presenta un nuevo protocolo para analizar las interacciones complejas de alteraciones genómicas en el desarrollo del cáncer. Ayuda a los investigadores a comprender cómo las mutaciones y las alteraciones del número de copias (CNA) trabajan juntas en contextos específicos de cáncer.

Palabras clave:
BioinformáticaCáncerGenómicaSecuenciaciónBiología de sistemas

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Área de la Ciencia:

  • Genómica
  • Biología del Cáncer
  • Bioinformática

Sus antecedentes:

  • Los conjuntos de datos de cáncer a gran escala son cruciales para comprender las alteraciones genómicas complejas en la tumorigénesis.
  • Los métodos existentes pueden no capturar completamente los diversos patrones de interacción entre las alteraciones genómicas.

Objetivo del estudio:

  • Presentar un protocolo para cuantificar diversos patrones de interacción entre alteraciones genómicas.
  • Permitir el análisis de interacciones genéticas específicas del contexto en el cáncer.

Principales métodos:

  • Preparación de una matriz de alteración binarizada a partir de conjuntos de datos de cáncer a gran escala.
  • Análisis de las asociaciones de mutaciones y alteraciones del número de copias (CNA).
  • Examen de asociaciones por pares, de orden superior y dependientes del contexto.

Principales resultados:

  • El protocolo cuantifica eficazmente diversos patrones de interacción de alteraciones genómicas.
  • Permite la identificación de interacciones genéticas específicas del contexto relevantes para la tumorigénesis.

Conclusiones:

  • Este protocolo proporciona un enfoque sistemático para analizar asociaciones complejas de alteraciones genómicas.
  • Facilita una comprensión más profunda de la base genética del desarrollo del cáncer.