Video Experimental Relacionado

Updated: Feb 15, 2026

Isolation of Murine Lymph Node Stromal Cells

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

Nodos linfáticos-nano-profármaco dirigido para la inmunorregulación precisa de las células B para prevenir la

Ning Li¹, Wenlong Huang², Zhaoshun Wu¹

¹Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 Wan-Ping South Road, Shanghai 200032, China; Spine Institute, Shanghai University of Traditional Chinese Medicine, 725 Wan-Ping South Road, Shanghai 200032, China.

|February 13, 2026

Abstract:

Rheumatoid arthritis (RA) is a systemic autoimmune disease marked by progressive joint destruction and deformities, which are irreversible once they develop. If the disease can be prevented in the preclinical stage, it may significantly reduce the rate of RA incidence and disability. However, insufficient attention has been paid to RA prevention. Herein, we proposed a nano-prodrug delivery (HC-IBR) to modulate the B cell immune response in lymph nodes (LNs) during the preclinical phase of RA. The HC-IBR was constructed by self-assembly of hyaluronic acid (HA) bearing cyanine7 (Cy7) and bruton tyrosine kinase inhibitor ibrutinib (IBR). The HC-IBR effectively targeted and specifically accumulated in LNs and further controlled IBR drug release under light irradiation. HC-IBR plus laser exhibited better efficiency in inhibition of antigen-presenting B cell and germinal center to control the development of joint inflammation in mice with collagen induced arthritis. This study provides a potential novel strategy for RA prevention by precise and localized B cell immunoregulation.

Palabras clave:

Célula B Ibrutinib Nano-profármaco dirigido a ganglios linfáticos Prevención y tratamiento de la artritis reumatoide

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