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Actividad de bucles R y expresión de CSDE1 en UCEC se correlacionan con mal pronóstico e inmunosupresión, lo que

Hui Liu¹, Yuanting Lai¹

¹Department of Gynecology, Guangzhou No.12 People's Hospital, Guangdong 510700, China.

Computational biology and chemistry

|February 13, 2026

Resumen

La actividad de bucles R y la expresión de CSDE1 están relacionadas con malos resultados en el carcinoma de endometrio del cuerpo uterino (UCEC). La focalización de CSDE1 puede ofrecer una nueva estrategia terapéutica para pacientes con UCEC, integrando la inestabilidad genómica y la inmunosupresión.

Área de la Ciencia:

Oncología; Biología Molecular; Genómica

Sus antecedentes:

Los bucles R, estructuras de ácido nucleico de tres hebras, están implicados en la inestabilidad genómica y la progresión del cáncer. La significancia pronóstica y el papel mecanicista de los bucles R en el carcinoma de endometrio del cuerpo uterino (UCEC) no se comprenden bien.

Objetivo del estudio:

Investigar la significancia pronóstica y el papel mecanicista de la actividad de bucles R y CSDE1 en UCEC. Desarrollar un modelo pronóstico para UCEC basado en genes de bucles R y CSDE1.

Principales métodos:

Análisis multiómicos de datos de UCEC de TCGA, incluyendo datos transcriptómicos, clínicos, mutacionales y espaciales. Modelado pronóstico, análisis de supervivencia, expresión diferencial, perfilado de CNV, comparaciones de mutaciones, transcriptómica unicelular y espacial. Experimentos funcionales in vivo e in vitro para evaluar el papel de CSDE1.

Principales resultados:

La actividad elevada de bucles R se correlacionó con un estadio avanzado de UCEC, alto grado y मला supervivencia. Un modelo pronóstico basado en genes de bucles R mostró una alta precisión predictiva. CSDE1 fue el gen predictivo principal. Los fibroblastos CSDE1⁺ se comunican con las células inmunes a través de la vía SPP1, promoviendo la proliferación y migración al reducir la acumulación de bucles R y el daño al ADN.

Conclusiones:

La actividad de bucles R y la expresión de CSDE1 definen un programa molecular en UCEC que involucra inestabilidad genómica, inmunosupresión y remodelación estromal. Los hallazgos respaldan el pronóstico estratificado y la focalización terapéutica de CSDE1 en el cáncer de endometrio.

Palabras clave:

CSDE1 Bucle R Transcriptómica unicelular Transcriptómica espacial Carcinoma de endometrio del cuerpo uterino

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