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Infecciones bacterianas post-influenza: Epidemiología, conocimientos mecanísticos y enfoques de tratamiento

Yueying Chen¹, Hong Li², Jingwen Mu³

¹The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosecurity, School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; College of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Journal of infection and public health

|February 13, 2026

Abstract:

Influenza virus is one of the most common viruses for respiratory tract infections. Postinfluenza bacterial infections can lead to severe pneumonia and significantly increase the mortality during influenza outbreaks. This review addresses the differences between primary influenza viral infection and postinfluenza bacterial infection and explores the underlying mechanisms of the secondary infection. The mechanisms entail the disruption of the lung barrier and the host immune system by influenza virus, as well as an increase in the availability of nutrients necessary for bacterial proliferation, which collectively lead to increased susceptibility to secondary infections. This review also discusses the current common clinical and novel therapeutic strategies to provide new insights for clinical diagnosis and treatment strategies.

Palabras clave:

Bacterias Virus de la influenza Enfermedades respiratorias Infección secundaria Tratamiento

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