Auricular stimulation therapy: An evidence-based practice strategy for depression

Auricular stimulation therapy (AST), encompassing transcutaneous auricular vagus nerve stimulation (taVNS) and auricular acupuncture, is gaining prominence as a non-pharmacological intervention for Depressive Disorders. Accumulating evidence from systematic reviews and randomized controlled trials (RCTs) demonstrate its efficacy in mitigating symptoms of Depressive Disorders, postpartum depression (PPD), post-stroke depression (PSD), with effects comparable to first-line antidepressants and a superior tolerability profile. Beyond symptom relief, AST is associated with improvements in sleep quality, cognitive function, and may serve as an adjunct to reduce antidepressant dosage. This review aims to systematically evaluate the current evidence on AST for depressive disorders and discuss its potential as a safe, effective, and medication-sparing clinical strategy.