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ASOCIACIÓN ENTRE GALECTINA-3 Y COMPLICACIONES MICROVASCULARES EN DIABETES MELLITUS TIPO 2: UN ESTUDIO COMPARATIVO
A Manzoorudeen1, I Ismail1, A Hashim1
1Department of Medical Laboratory Science, College of Health Sciences, Gulf Medical University, Ajman, UAE.
Georgian medical news
|February 13, 2026
Resumen
Los niveles séricos de galectina-3 son más altos en pacientes con diabetes mellitus tipo 2 (DM2) con complicaciones microvasculares. Sin embargo, la galectina-3 no es un predictor independiente de estas complicaciones después de ajustar por IMC y control glucémico.
Área de la Ciencia:
- Endocrinología
- Nefrología
- Inmunología
Sus antecedentes:
- La galectina-3, una lectina implicada en la inflamación y la fibrosis, participa en la patogénesis de la diabetes mellitus tipo 2 (DM2) y sus complicaciones microvasculares. Se observan niveles elevados de galectina-3 en afecciones inflamatorias y fibróticas.
Objetivo del estudio:
- Investigar la asociación entre los niveles séricos de galectina-3 y las complicaciones microvasculares en pacientes con DM2.
- Determinar si esta asociación persiste después de controlar los factores clínicos.
Principales métodos:
- Estudio transversal comparativo de 64 participantes (32 con DM2 y complicaciones microvasculares, 32 controles).
- Se midieron los niveles séricos de galectina-3 mediante ELISA.
- Se evaluaron parámetros clínicos (IMC, HbA1c, etc.) y microalbuminuria.
- Se realizó un análisis de regresión lineal multivariante.
Principales resultados:
- Los niveles séricos de galectina-3 fueron significativamente más altos en pacientes con DM2 y complicaciones microvasculares en comparación con los controles (p<0.001).
- La galectina-3 mostró correlaciones positivas fuertes con la microalbuminuria (p<0.001) y correlación moderada con la HbA1c (p<0.001).
- La galectina-3 no se asoció de forma independiente con la microalbuminuria después del ajuste por IMC, HbA1c y edad (p=0.197); la HbA1c se mantuvo significativa (p<0.001).
Conclusiones:
- La elevación de la galectina-3 sérica en pacientes con DM2 y complicaciones microvasculares no predice de forma independiente estas complicaciones.
- La galectina-3 puede indicar una carga metabólica e inflamatoria subyacente en lugar de ser un predictor independiente.
- El control glucémico (HbA1c) sigue siendo un predictor independiente clave de las complicaciones microvasculares en la DM2.
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