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Updated: Feb 15, 2026

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Captura de la proteasa principal del SARS-CoV-2 en zimógenos artificiales transitorios para expresión de alto

Pavel Novotný1, Adéla Moravcová2, Veronika Nováková3

  • 1Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic; Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Prague, Czech Republic.

International journal of biological macromolecules
|February 13, 2026
PubMed
Resumen

Tres estrategias de expresión producen Mpro principal (Mpro) de SARS-CoV-2 de alta calidad para la investigación. Todos los métodos producen Mpro activa con N-terminales auténticos, adecuados para estudios bioquímicos y estructurales.

Palabras clave:
Purificación de proteínasProteasa principal del SARS-CoV-2Zimógeno

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