Video Experimental Relacionado
Updated: Feb 15, 2026
12:19
Three-Dimensional 3D Tumor Spheroid Invasion Assay
Published on: May 1, 2015
59.7K
El gen TP53 contiene una caja de diversidad que lo convierte en algo más que un supresor de tumores
Arnold J Levine1, Pierre Hainaut2
1Institute for Advanced Study, Princeton, NJ, USA. alevine@ias.edu.
Cell death and differentiation
|February 13, 2026
Resumen
La proteína p53, un supresor de tumores clave, tiene una "caja de diversidad" única que regula sus funciones e isoformas. Las variaciones genéticas en esta caja pueden explicar las diferencias en el cáncer entre ancestros.
Sus antecedentes:
- La proteína p53 es un supresor de tumores crítico, con mutaciones en TP53 encontradas en más del 50% de los cánceres.
- p53 actúa como una barrera contra la expansión de células transformadas, destacando su papel fundamental en la prevención del cáncer.
Conclusiones:
- La caja de diversidad de TP53 juega un papel crucial en el ajuste fino de las funciones de p53 y los fenotipos celulares.
- Las variaciones genéticas en la caja de diversidad pueden contribuir a diferencias específicas de la población en la epidemiología y patología del cáncer.
Palabras clave:
TP53p53caja de diversidadisoformas de p53polimorfismos de TP53haplotipos de TP53supresor de tumorescáncerMás Videos Relacionados
07:44Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice
Published on: February 17, 2023
2.1K
10:04Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models
Published on: March 13, 2018
12.6K
Videos de Conceptos Relacionados
01:12Loss of Tumor Suppressor Gene Functions
6.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
6.1K
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
9.9K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.9K
01:13Cell Diversity
5.2K
The concept of a cell started with microscopic observations of dead cork tissue by Robert Hooke in 1665. Hooke coined the term "cell" based on the resemblance of the small subdivisions in the cork to the rooms that monks inhabited, called cells. About ten years later, Antonie van Leeuwenhoek became the first person to observe the living and moving cells under a microscope. In the century that followed, the theory that cells represented the basic unit of life developed.
Multicellular...
Multicellular...
5.2K
01:24Diversity of Archaea II
555
Archaea, one of the three domains of life, exhibit remarkable diversity and adaptability, thriving in both extreme and moderate environments. Historically, most identified archaea have been classified into two major phyla: Euryarchaeota and Crenarchaeota. However, recent molecular studies have expanded this classification to include three additional phyla: Thaumarchaeota, Nanoarchaeota, and Korarchaeota, each exhibiting unique characteristics and ecological roles.Thaumarchaeota: Mesophiles...
555
01:15Diversity of Protists I
1.2K
Excavata is a diverse group of protists that includes both chemoorganotrophic and phototrophic species, with some thriving in anaerobic environments. Among the key groups within Excavata are diplomonads and parabasalids, which are flagellated protists that lack mitochondria and chloroplasts. These microorganisms typically inhabit anoxic environments, such as the intestines of animals, where they exist either symbiotically or as parasites, relying on fermentation for energy production. Some...
1.2K
01:27Diversity of Protists II
1.2K
Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
1.2K