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Avances en el muestreo mediastínico en linfadenopatías no metastásicas

Reto Engeli¹, Carolin Steinack¹, Juergen Hetzel²

¹Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland.

Med (New York, N.Y.)

|February 14, 2026

Abstract:

Despite advances in PET/CT, tissue confirmation remains essential for mediastinal lymphadenopathy. EBUS-TBNA is minimally invasive but limited by cytology, particularly in benign disease and lymphoma. Emerging EBUS-guided techniques, notably transbronchial mediastinal cryobiopsy, improve diagnostic yield where tissue architecture is required. The multicenter randomized study¹ strengthens evidence for its added value, while underscoring the need for selective application and standardized, indication-specific trials.

Palabras clave:

ultrasonido endobronquial aspiración con aguja transbronquial criobiopsia linfadenopatía mediastínica diagnóstico tisular linfoma enfermedades benignas

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