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Tolerancia a los antibióticos y seguridad en la endocarditis infecciosa: un enfoque en pacientes de edad avanzada

Capucine Richard¹, Sylvain Gautier², Pierre Boisson DE Chazournes³

¹Geriatrics department, University Hospital A. Paré, Versailles St Quentin University, APHP, Boulogne-Billancourt, France.

Infectious diseases now

|February 14, 2026

Abstracto

Background:

Infective endocarditis (IE) is a rare but severe disease with high morbidity and mortality, increasingly affecting older adults. Data on antibiotic tolerance in this population remain limited.

Methods:

We conducted a hospital network cohort study including all patients over 65 years old. diagnosed with IE between May 2016 and August 2024 in the greater Paris area. Antibiotic-related adverse events (AEs) were systematically collected, within six months of follow-up.

Results:

Among 83 patients (median age: 84 years), 21 (25.3%) experienced at least one AE. Patients with AEs had longer hospital stays but similar age, autonomy, and in-hospital outcomes compared to those without AEs. Cognitive impairment was significantly associated with a higher risk of AEs, particularly in patients aged ≥ 75 years. Streptococcal IE was less frequently associated with AEs. Most AEs were biological abnormalities or clinical events, mainly involving amoxicillin and cefazolin.

Conclusions:

Age alone did not markedly affect antibiotic tolerance.

Palabras clave:

eventos adversos de medicamentos deterioro cognitivo endocarditis infecciosa atención multidisciplinaria adultos mayores

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