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Updated: Feb 16, 2026

Arthroscopic Management of Massive Irreparable Rotator Cuff Tears: Whole Rotator Cable Reconstruction Using Proximal Biceps Tendon Autograft

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Tideglusib acelera la curación de la interfaz hueso-tendón y mejora la resistencia mecánica en un modelo de desgarro

Zeynel Can Ocaklar¹, Murat Serkant Ünal², A Çağdaş Yörükoğlu³

¹Orthopedics and Traumatology Department, Pamukkale University Medical Faculty, 20070, Pamukkale, Denizli, Turkey.

Journal of orthopaedic surgery and research

|February 14, 2026

Abstracto

Background:

The present study aimed to investigate the effects of the glycogen synthase kinase-3 (GSK-3) inhibitor tideglusib on bone-tendon interface healing in a rabbit model of rotator cuff injury, based on biomechanical and histological assessments.

Methods:

Fourteen New Zealand rabbits underwent supraspinatus tendon detachment to establish a chronic rotator cuff tear model. After six weeks, surgical repair was performed. In the right shoulders, tideglusib was administered at the bone-tendon junction prior to performing the primary repair (drug group), whereas the left shoulders underwent primary repair without biological augmentation (control group). Seven animals were included in the group subjected to biomechanical tension testing, and six for histological evaluation.

Results:

Biomechanical evaluation demonstrated that the tideglusib group showed significantly higher load-to-failure values compared with the control group the control group (p < 0.05), whereas elongation at failure showed no statistically significant difference. Histological scoring demonstrated significantly improved cellular organization and tissue healing in the tideglusib group (p < 0.05).

Conclusion:

Local application of tideglusib positively enhances tendon-bone healing both biomechanically and histologically. Further studies are warranted to explore its potential clinical applications.

Palabras clave:

Curación de la interfaz hueso-tendón Manguito rotador Tideglusib

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