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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

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Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Video Experimental Relacionado

Updated: Feb 17, 2026

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
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Envejecimiento renal: modelos de investigación, intervenciones y tendencias de desarrollo

Yongpan An1, Ruixiao Li2, Rui Zhang3

  • 1Department of Urology, Xi'an People's Hospital (Xi'an Fourth Hospital), School of Life Sciences and Medicine, Northwest University, Xi'an, Shaanxi 710199, China; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Air Force Medical University, Xi'an, Shaanxi, China.

Drug discovery today
|February 15, 2026
PubMed
Resumen
Este resumen es generado por máquina.

El envejecimiento renal provoca daños y enfermedades, especialmente en los ancianos. Esta revisión cubre los cambios renales del envejecimiento, los modelos de senescencia y las estrategias para retrasar el envejecimiento y mejorar la salud renal.

Palabras clave:
intervencionesmodelos de envejecimiento renalenvejecimiento renal

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Área de la Ciencia:

  • Nefrología
  • Gerontología
  • Biología Molecular

Sus antecedentes:

  • El riñón envejecido es susceptible al daño y es un factor de riesgo para enfermedades renales.
  • La enfermedad renal crónica en los ancianos es una creciente preocupación de salud mundial.
  • Los avances en la comprensión de los mecanismos moleculares y celulares del envejecimiento renal son cruciales.

Objetivo del estudio:

  • Resumir las alteraciones patológicas en el riñón envejecido.
  • Explorar modelos de enfermedades de senescencia renal.
  • Revisar estrategias potenciales para retrasar el envejecimiento renal.

Principales métodos:

  • Revisión de la literatura sobre los cambios patológicos en los riñones envejecidos.
  • Exploración sistemática de los modelos de enfermedades de senescencia renal.
  • Análisis de intervenciones potenciales para retrasar el envejecimiento renal.

Principales resultados:

  • Descripción detallada de los cambios patológicos relacionados con la edad en la estructura y función renal.
  • Descripción general de los modelos establecidos y emergentes para el estudio de la senescencia renal.
  • Identificación de dianas terapéuticas y estrategias para mitigar el envejecimiento renal.

Conclusiones:

  • La comprensión de los mecanismos del envejecimiento renal es clave para prevenir las enfermedades renales relacionadas con la edad.
  • Los modelos de enfermedades proporcionan información sobre la senescencia y las intervenciones potenciales.
  • Las estrategias para retrasar el envejecimiento renal ofrecen una base teórica para la investigación futura y la práctica clínica.