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Updated: Feb 17, 2026

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT

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Cambios en la gammagrafía con pirofosfato después de la terapia con tafamidis - Índice novedoso propuesto de

Tsuneaki Yoshinaga^1,2, Shin Yanagisawa³, Masatoshi Minamisawa^4,5

¹Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine.

Circulation journal : official journal of the Japanese Circulation Society

|February 15, 2026

Abstracto

Background:

Because a disease-modifying therapy is now available, bone scintigraphy plays a crucial role in diagnosing transthyretin cardiac amyloidosis (ATTR-CM).

Methods And Results:

We retrospectively analyzed 24 patients with ATTR-CM to determine the amyloid accumulation volume (AAV: mean standardized uptake value×volume) of the left ventricular wall. AAV showed a significant decrease (591.1±426.0 vs. 213.8±201.9, P<0.0001) after tafamidis treatment, and correlated with troponin T (R=0.49, P=0.022).

Conclusions:

AAV provided a precise quantitative evaluation of the amyloid burden in ATTR-CM.

Palabras clave:

ATTR-CM Gammagrafía con pirofosfato Tafamidis

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