Video Experimental Relacionado

Updated: Feb 17, 2026

Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness

Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness

Published on: December 6, 2024

Optimización de la sección de información clave de los documentos de consentimiento informado en la investigación

Shahana Chumki¹, Caleb Smith², Terri Ridenour¹

¹Office of the Vice President for Research, University of Michigan, Ann Arbor, MI, USA.

Journal of clinical and translational science

|February 16, 2026

Abstracto

Introduction:

Informed consent is a cornerstone of ethical research, but the lack of widely accepted standards for the key information (KI) section in informed consent documents (ICDs) creates challenges in institutional review board (IRB) reviews and participant comprehension. This study explored the use of GPT-4o, a large language model (collectively, AI), to generate standardized KI sections.

Methods:

An AI tool was developed to interpret and generate KI content from ICDs. The evaluation involved a multi-phased process where IRB subject matter experts, principal investigators (PIs), and IRB reviewers assessed the AI output for accuracy, differentiation between standard care and research, appropriate information prioritization, and structural coherence.

Results:

Iterative refinements improved the AI's accuracy and clarity, with initial assessments highlighting factual errors that decreased over time. Many PIs found the AI-generated sections comparable to their own and expressed a high likelihood of using the tool for future drafts. Blinded evaluations by IRB reviewers highlighted the AI tool's strengths in describing study benefits and maintaining readability. However, the findings underscore the need for further improvements, particularly in ensuring accurate risk descriptions, to enhance regulatory compliance and IRB reviewer confidence.

Conclusions:

The AI tool shows promise in enhancing the consistency and efficiency of KI section drafting in ICDs. However, it requires ongoing refinement and human oversight to fully comply with regulatory and institutional standards. Collaboration between AI and human experts is essential to maximize benefits while maintaining high ethical and accuracy standards in informed consent processes.

Palabras clave:

Consentimiento GPT-4o comité de ética institucional información clave modelo de lenguaje grande

Más Videos Relacionados

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

Constructing and Visualizing Models using Mime-based Machine-learning Framework

Constructing and Visualizing Models using Mime-based Machine-learning Framework

Published on: July 22, 2025

Videos de Conceptos Relacionados

Improving Translational Accuracy

Improving Translational Accuracy

Improving Translational Accuracy

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...

Clinical Trials: Overview

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...

Bioequivalence: Overview

Bioequivalence: Overview

Pharmaceutical equivalents, by definition, are drug products with the same active ingredient in the same quantities, encapsulated in identical dosage forms, and intended for the same administration routes. These pharmaceutical equivalents are deemed bioequivalent if the bioavailability of the active entity in the drug preparations is similar. Moreover, pharmaceutical equivalents demonstrating bioequivalence are also regarded as therapeutically equivalent. This means that when used as directed,...

Biopharmaceutics and Pharmacokinetics: Overview

Biopharmaceutics and Pharmacokinetics: Overview

Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...