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Plasmodium knowlesi puede adaptarse para infectar eritrocitos Duffy-negativos
Maria Mgella Zinga1, Amy Ibrahim2, Franziska Mohring2
1Mahidol University, Faculty of Tropical Medicine, Bangkok, Thailand.
Blood
|February 17, 2026
Resumen
Plasmodium knowlesi puede invadir glóbulos rojos Duffy-negativos al eludir el receptor de antígeno Duffy para quimiocinas (DARC). Un nuevo gen quimérico, dbpαγ, permite esta invasión, impactando la dinámica de transmisión de la malaria.
Área de la Ciencia:
- Malariología
- Parasitología
- Genética
Sus antecedentes:
- Plasmodium knowlesi es un parásito de la malaria zoonótica que causa una incidencia creciente en el sudeste asiático.
- La invasión de P. knowlesi típicamente requiere el receptor de antígeno Duffy para quimiocinas (DARC), afectando a individuos Duffy-positivos.
Objetivo del estudio:
- Investigar la plasticidad de invasión de P. knowlesi.
- Comprender los mecanismos que permiten a P. knowlesi invadir eritrocitos Duffy-negativos.
Principales métodos:
- Adaptación in vitro de P. knowlesi a eritrocitos Duffy-negativos.
- Análisis genómico para identificar modificaciones genéticas.
- Edición génica CRISPR-Cas9 para validar la función génica.
Principales resultados:
- P. knowlesi se adaptó para invadir y replicarse en eritrocitos Duffy-negativos, independientemente de DARC.
- Se identificó un nuevo gen quimérico, dbpαγ, resultante de la recombinación entre dbpα y dbpγ.
- El gen dbpαγ es esencial para la invasión de eritrocitos Duffy-negativos.
Conclusiones:
- P. knowlesi exhibe una mayor plasticidad de invasión de la que se conocía previamente.
- El gen dbpαγ facilita la invasión independiente de DARC, lo que podría ampliar el rango de huéspedes del parásito.
- Los hallazgos tienen implicaciones para la epidemiología de la malaria y la investigación de la especificidad de la célula huésped.
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