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Updated: Feb 19, 2026

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Asociación entre la enfermedad de Behçet y los resultados relacionados con el embarazo: una revisión sistemática y

Kai-Wen Chuang¹, Ching-Yu Wang², Buo-Jia Lu³

¹Department of Dermatology, Taipei Medical University Hospital, Taipei, Taiwan.

Journal of reproductive immunology

|February 17, 2026

Abstract:

Behçet disease (BD) is a chronic autoinflammatory disorder characterized by systemic vasculitis. It is highly prevalent in women of reproductive age and may increase the risk of pregnancy-related complications. This study evaluated the impact of BD on maternal, obstetric, and fetal outcomes. A systematic search of PubMed, Scopus, Web of Science, and the Cochrane Library was conducted for studies comparing pregnancy-related outcomes between women with BD and controls, up to January 27, 2025. A random-effects model was used for the meta-analysis, and results were calculated as Mantel-Haenszel risk ratios (MH RRs) with 95 % confidence intervals (CIs). Seven cohort studies comprising 498 BD pregnancies and 14,943,476 controls were included. BD was associated with significantly higher risks of thromboembolic events (MH RR = 19.480; 95 % CI = 9.839-38.567), miscarriage (MH RR = 2.736; 95 % CI = 1.026-7.297), cesarean delivery (MH RR = 1.442; 95 % CI = 1.253-1.658), fetal growth restriction (FGR; MH RR = 2.368; 95 % CI = 1.392-4.027), and fetal abnormalities (MH RR = 2.011; 95 % CI = 1.129-3.581). Subgroup analysis revealed a significantly higher risk of gestational diabetes mellitus in Asian women with BD (MH RR = 3.613; 95 % CI = 1.038-12.572). Pregnant women with BD have significantly increased risks of thromboembolic events, miscarriage, cesarean delivery, FGR, and fetal abnormalities. These findings underscore the importance of multidisciplinary care to optimize maternal and fetal outcomes.

Palabras clave:

enfermedad de Behçet cesárea anomalías fetales restricción del crecimiento fetal aborto espontáneo eventos tromboembólicos

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