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Updated: Feb 19, 2026

Preparation of Pseudo-Typed H5 Avian Influenza Viruses with Calcium Phosphate Transfection Method and Measurement of Antibody Neutralizing Activity

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Solución acuosa desinfectante de amplio espectro que contiene catión de amonio cuaternario y sulfobetaína es eficaz

Masahiko Morioka¹, Yohei Takeda², Mamoru Ohnishi³

¹Future Cell Japan Corp., Tokyo Metropolitan Industrial Technology Research Institute 318, 2-4-10 Aomi Koto-ku, Tokyo 135-0064, Japan.

Bioorganic & medicinal chemistry letters

|February 17, 2026

Abstract:

Highly pathogenic avian influenza virus (HPAIV) is an enveloped virus currently spreading among birds around the world, and infections in humans have been reported. Common disinfectants such as ethanol and chlorine are somewhat effective, but the development of more effective disinfectants to prevent infection is urgently needed. As a result of a series of studies focusing on cationic antibacterial agents, DEA-171 has been developed as a safe and effective anti-enveloped virus by adding sulfobetaine to a specific quaternary ammonium cation. This solution inactivated approximately 99.0% of H5 HPAIV in 30 min.

Palabras clave:

Virus de la influenza aviar altamente patógena (VPAAP)Agente neutralizante Desinfectante no alcohólico Agente virucida

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