Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Speciation Rates01:07

Speciation Rates

23.0K
Overview
23.0K
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

738
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
738
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

41.8K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
41.8K
Applications of Molecular Taxonomy01:20

Applications of Molecular Taxonomy

597
Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...
597
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

7.1K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.1K
Eukaryotic Evolution01:24

Eukaryotic Evolution

42.6K
The endosymbiont theory is the most widely accepted theory of eukaryotic evolution; however, its progression is still somewhat debated. According to the nucleus-first hypothesis, the ancestral prokaryote first evolved a membrane to enclose DNA and form the nucleus. Conversely, the mitochondria-first hypothesis suggests that the nucleus was formed after endosymbiosis of mitochondria.
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
42.6K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Noncanonical genetic markers resolve the pre-GOE emergence of aerobic bacteria in Earth's history.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Quantitative-genetic analysis of directional adaptation suggests low maximum sustainable rates of change in agreement with data from field populations.

Scientific reports·2025
Same author

The radiation and geographic expansion of primates through diverse climates.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Trait macroevolution in the presence of covariates.

Nature communications·2025
Same author

Dating the Bacterial Tree of Life Based on Ancient Symbiosis.

Systematic biology·2025
Same author

Dating Ammonia-Oxidizing Bacteria with Abundant Eukaryotic Fossils.

Molecular biology and evolution·2024

Video Experimental Relacionado

Updated: Feb 19, 2026

Author Spotlight: Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons
07:59

Author Spotlight: Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons

Published on: June 9, 2023

2.0K

Datación del reloj molecular utilizando modelos de mezcla complejos: aplicado a simbiontes antiguos

Sishuo Wang1, Andrew Meade2

  • 1Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.

Molecular biology and evolution
|February 18, 2026
PubMed
Resumen

El nuevo software, phyloHessian, mejora la precisión del reloj molecular utilizando modelos de sustitución complejos. Esto mejora la fiabilidad de la línea de tiempo evolutiva para linajes de tiempo profundo y de rápida evolución.

Palabras clave:
MCMCtreePAMLverosimilitud aproximadamodelo de mezcla complejoevolución de tiempo profundoreloj molecularevolución de patógenossimbionte

Más Videos Relacionados

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

23.2K
Author Spotlight: Understanding Microbe Adaptation Using Innovative Techniques for Exploring Thermophilic Evolution
08:11

Author Spotlight: Understanding Microbe Adaptation Using Innovative Techniques for Exploring Thermophilic Evolution

Published on: June 14, 2024

1.5K

Videos de Experimentos Relacionados

Last Updated: Feb 19, 2026

Author Spotlight: Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons
07:59

Author Spotlight: Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons

Published on: June 9, 2023

2.0K
Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

23.2K
Author Spotlight: Understanding Microbe Adaptation Using Innovative Techniques for Exploring Thermophilic Evolution
08:11

Author Spotlight: Understanding Microbe Adaptation Using Innovative Techniques for Exploring Thermophilic Evolution

Published on: June 14, 2024

1.5K

Área de la Ciencia:

  • Biología Evolutiva
  • Biología Computacional
  • Filogenética

Sus antecedentes:

  • Los relojes moleculares son cruciales para la cronología evolutiva, pero a menudo son inexactos debido a modelos de sustitución simples.
  • La heterogeneidad de sustitución y la saturación en linajes de tiempo profundo o de rápida evolución comprometen los métodos actuales del reloj molecular.

Objetivo del estudio:

  • Introducir phyloHessian, un software basado en Julia para la datación molecular utilizando modelos de sustitución de mezcla complejos.
  • Mejorar la precisión de las estimaciones del tiempo de divergencia y la tasa de sustitución en los análisis del reloj molecular.

Principales métodos:

  • phyloHessian calcula la matriz Hessiana filogenética.
  • Integra la matriz Hessiana en el marco de verosimilitud aproximada de PAML-MCMCtree para la datación.
  • Utiliza modelos de sustitución de mezcla complejos en lugar de homogéneos.

Principales resultados:

  • Los modelos de mezcla complejos mejoran significativamente la precisión del tiempo de divergencia y la tasa de sustitución en filogenias de tiempo profundo.
  • Los modelos de mezcla muestran una mayor robustez a las incertidumbres del modelo y la calibración en comparación con los modelos homogéneos.
  • Los análisis empíricos revelaron tasas de sustitución aceleradas y tiempos de divergencia alterados para Microsporidia y Rickettsiales.

Conclusiones:

  • La incorporación de modelos de sustitución de mezcla complejos es vital para obtener líneas de tiempo evolutivas fiables.
  • phyloHessian mejora el estudio de linajes de tiempo profundo o de rápida evolución.
  • Se sugieren historias evolutivas revisadas y orígenes de asociación de huéspedes para simbiontes antiguos.