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Updated: Feb 19, 2026
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Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
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La separación de fases de ERG atenúa la senescencia celular
Lu Pu1,2, Zhiliang Zuo3,4,5, Hui Zheng6
1Laboratory for Aging and Cancer Research, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
iScience
|February 18, 2026
Resumen
Los centenarios exhiben una accesibilidad de la cromatina única vinculada a la longevidad. El factor de transcripción ERG regula el envejecimiento celular a través de la separación de fases, reduciendo la senescencia y promoviendo la resiliencia en la vejez extrema.
Área de la Ciencia:
- Genómica
- Epigenética
- Biología Celular
Sus antecedentes:
- Los centenarios ofrecen información sobre los mecanismos de envejecimiento saludable.
- Comprender la base molecular de la longevidad es crucial para desarrollar intervenciones.
Objetivo del estudio:
- Identificar factores epigenéticos y moleculares asociados con la longevidad excepcional en centenarios.
- Investigar el papel del factor de transcripción ERG en el envejecimiento celular y la senescencia.
Principales métodos:
- Perfilado transcriptómico y ATAC-seq de células mononucleares de sangre periférica de centenarios.
- Análisis bioinformático integrador para identificar reguladores clave.
- Estudios funcionales en células humanas para evaluar las propiedades biofísicas de ERG y sus efectos sobre la senescencia.
Principales resultados:
- Se identificó un paisaje distinto de accesibilidad de la cromatina en centenarios.
- Se destacó el factor de transcripción ERG como un regulador asociado con la longevidad.
- ERG forma condensados nucleares a través de la separación de fases líquido-líquido, reduciendo la expresión de genes relacionados con la senescencia (por ejemplo, CDKN2A) y atenuando los fenotipos de senescencia celular.
Conclusiones:
- Las características epigenómicas en centenarios están vinculadas a las propiedades biofísicas de los factores de transcripción.
- La separación de fases de ERG es un mecanismo regulador novedoso en el control del envejecimiento celular.
- La separación de fases puede contribuir a la resiliencia celular y la longevidad.
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