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Updated: May 7, 2026

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Inhibición de MEK para la terapia de células CAR-T: un enfoque para el síndrome de liberación de citoquinas y la

Hui Li^1,2, Youming Wang^1,2, Yingxiang Wang¹

¹Department of Hematology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.

British journal of haematology

|February 18, 2026

Abstract:

This study presents mitogen-activated protein kinase kinase (MEK) inhibition as a strategy for cytokine release syndrome (CRS) and secondary haemophagocytic lymphohistiocytosis (sHLH) in chimeric antigen receptor (CAR)-T therapy, utilizing MEK's regulatory actions that target macrophage activation, cytokine secretion from both macrophages and CAR-T cells, supported by evidence of unimpaired CAR-T-cell therapeutic efficacy of alleviated CAR-T-related inflammation.

Palabras clave:

terapia CAR-T inhibidor de MEK síndrome de liberación de citoquinas macrófago linfohistiocitosis hemofagocítica secundaria

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