Video Experimental Relacionado

Updated: Feb 20, 2026

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Published on: August 11, 2023

Aprendizaje automático para predecir resultados y frecuencia de dosificación con aflibercept para edema macular tras

Nitish Mehta¹, Yasha Modi¹, Fabiana Q Silva²

¹Department of Ophthalmology, NYU Langone Health, New York.

Ophthalmic surgery, lasers & imaging retina

|February 18, 2026

Abstracto

Background And Objective:

This study aimed to develop machine learning algorithms to predict visual and anatomic outcomes and treatment frequency in patients with macular edema following central retinal vein occlusion (MEfCRVO) after intravitreal aflibercept injections (IAI).

Patients And Methods:

Data from patients from the COPERNICUS (n = 107) and GALILEO (n = 91) trials treated with monthly IAI 2 mg for 24 weeks then pro re nata (PRN) through week 52 were used to develop machine learning algorithms.

Results:

Machine learning algorithms predicted actual values at week 52 with strong correlation for absolute best-corrected visual acuity (BCVA) (r = 0.87), BCVA change from baseline (r = 0.76), ≥ 15-letter gain (area under the curve [AUC] = 0.81), and change in central subfield thickness from baseline (r = 0.76). PRN injection frequency from week 24 to 52 was predicted with high accuracy (AUC = 0.83). Univariate analyses confirmed all predictive factors.

Conclusion:

Machine learning algorithms predicted outcomes and dosing frequency with high accuracy and may help inform patients' and clinicians' expectations during MEfCRVO management.

Palabras clave:

aprendizaje automático edema macular oclusión de vena retiniana central aflibercept agudeza visual frecuencia de inyección

Más Videos Relacionados

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Published on: August 6, 2021

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents

Published on: September 16, 2020

Videos de Conceptos Relacionados

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...