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Ritmos circadianos en el envejecimiento y la longevidad: de la cronómica molecular a la gerontología traslacional
Anita Jagota1, Han Wang2,3,4, Yujiro Yamanaka4
1Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, China. ajsl@uohyd.ac.in.
Biogerontology
|February 18, 2026
Resumen
El envejecimiento deteriora las funciones corporales, pero la biología circadiana ofrece resiliencia. Esta colección explora cómo los ritmos circadianos impactan el envejecimiento, la longevidad y las enfermedades relacionadas en diversos campos.
Área de la Ciencia:
- Gerontología
- Cronobiología
- Biología Molecular
Sus antecedentes:
- El envejecimiento conduce a un declive fisiológico y a un mayor riesgo de enfermedad.
- La biología circadiana, centrada en el sistema de temporización circadiana (CTS), es cada vez más reconocida por su papel en el mantenimiento de la homeostasis y la resiliencia.
- Las señales ambientales de tiempo interactúan con el CTS para regular los ritmos fisiológicos y conductuales diarios.
Objetivo del estudio:
- Presentar una colección de investigaciones sobre el papel de los ritmos circadianos en el envejecimiento y la longevidad.
- Consolidar hallazgos en aspectos moleculares, inmunológicos, neurodegenerativos y metabólicos del envejecimiento.
- Destacar la regulación circadiana como un principio unificador en la investigación del envejecimiento.
Principales métodos:
- Compilación de 16 artículos originales y de revisión.
- Los estudios abarcan diversos campos, como la cronómica molecular, el envejecimiento inmunológico, las enfermedades neurodegenerativas y el metabolismo.
- Inclusión de perspectivas computacionales y traslacionales.
Principales resultados:
- Los ritmos circadianos juegan un papel crucial en el mantenimiento de la homeostasis fisiológica durante el envejecimiento.
- Las interrupciones en la sincronización circadiana se asocian con una mayor vulnerabilidad a las enfermedades relacionadas con la edad.
- La regulación circadiana influye en la resiliencia celular, tisular y del organismo.
Conclusiones:
- La biología circadiana ofrece un marco unificador para comprender el envejecimiento y la longevidad.
- Una mayor investigación sobre los ritmos circadianos puede informar estrategias para promover un envejecimiento saludable y combatir las enfermedades relacionadas con la edad.
- La colección enfatiza la importancia global de la investigación circadiana en gerontología.
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