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Terapia redox para trastornos neuropsiquiátricos: mecanismos moleculares y desarrollo de biomarcadores
Kyle W Cuklanz1, Abigail Stein1,2, Virginie-Anne Chouinard1,3
1Psychotic Disorders Division, McLean Hospital, Belmont, MA 02478, USA.
Science advances
|February 18, 2026
Resumen
El desequilibrio redox en la nicotinamida adenina dinucleótido (NAD+) afecta los trastornos cerebrales. La restauración del equilibrio de NAD+ es prometedora, pero el éxito clínico requiere una mejor comprensión y biomarcadores para las enfermedades neurodegenerativas.
Sus antecedentes:
- La desregulación redox, específicamente el desequilibrio de la relación nicotinamida adenina dinucleótido (NAD+)/NADH, está relacionada con afecciones neurodegenerativas y psiquiátricas.
- Este desequilibrio exacerba la disfunción mitocondrial, el estrés oxidativo y la neuroinflamación, lo que contribuye a la patología de la enfermedad.
- Las estrategias terapéuticas actuales dirigidas al equilibrio redox han mostrado una eficacia clínica limitada debido a la comprensión incompleta del metabolismo de NAD+ y la falta de biomarcadores in vivo.
Conclusiones:
- La restauración del equilibrio redox a través de terapias dirigidas a NAD+ tiene potencial para tratar trastornos neurodegenerativos y psiquiátricos.
- La investigación adicional sobre la dinámica subcelular de NAD+ y el desarrollo de biomarcadores in vivo validados son fundamentales para el éxito clínico.
- Los enfoques personalizados y dirigidos por mecanismos, informados por neuroimagen avanzada, son clave para optimizar los resultados terapéuticos.
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