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Updated: Feb 20, 2026

Using Scaffold Liposomes to Reconstitute Lipid-proximal Protein-protein Interactions In Vitro

Using Scaffold Liposomes to Reconstitute Lipid-proximal Protein-protein Interactions In Vitro

Published on: January 11, 2017

El Intereactoma Lipídico: Una plataforma interactiva y de acceso abierto para explorar interacciones celulares

Gaelen Guzman¹, André Nadler², Frank Stein³

¹Department of Molecular Immunology & Immunology, Oregon Health & Science University, Portland, OR United States.

Bioinformatics (Oxford, England)

|February 18, 2026

Abstract:

Lipid-protein interactions play essential roles in cellular signaling and membrane dynamics, yet their systematic characterization has long been hindered by the inherent biochemical properties of lipids. Recent advances in functionalized lipid probes-equipped with photoa c tivatable crosslinkers, affinity handles, and photocleavable protecting groups-have en a bled proteomics-based identification of lipid interacting proteins with unprecedented spec i ficity and resolution. Despite the growing number of published lipid interactomes, there r e mains no centralized effort to harmonize, compare, or integrate these datasets. The Lipid Interactome addresses this gap by providing a structured, interactive web portal that a d heres to FAIR data principles-ensuring that lipid interactome studies are Findable, Acce s sible, Interoperable, and Reusable. Through standardized data formatting, interactive vis u alizations, and direct cross-study comparisons, this resource enables researchers to sy s tematically explore the protein-binding partners of diverse bioactive lipids. By consolidating and curating lipid interactome proteomics data from multiple studies, the Lipid Interactome database serves as a critical tool for deciphering the biological functions of lipids in cellular systems.

Availability:

This site can be viewed at LipidInteractome.org all data is available for dow n load. No user information is collected or necessary for data navigation, interaction, or dow n load.

Palabras clave:

interactoma lipídico interacciones lípido-proteína base de datos proteómica biología molecular bioquímica FAIR data

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