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Olvido acelerado a largo plazo en personas con epilepsia focal recién diagnosticada

C F Jackson¹, S M Makin², R Mohanraj²

¹The University of Liverpool, Liverpool, UK.

Epilepsy & behavior : E&B

|February 18, 2026

Resumen

El olvido acelerado a largo plazo (ALF, por sus siglas en inglés) afecta a pacientes con epilepsia recién diagnosticada (NDE), mostrando una disminución de la memoria a lo largo de semanas, no solo en la evocación inmediata. Esto sugiere que la intervención temprana es crucial para el manejo de los déficits cognitivos en la epilepsia.

Área de la Ciencia:

Neurociencia; Psicología Cognitiva; Neurología Clínica

Sus antecedentes:

Se sabe que el olvido acelerado a largo plazo (ALF) se presenta en la epilepsia crónica.; Los cambios cognitivos en las primeras etapas de la epilepsia están poco estudiados.; La evaluación cognitiva temprana puede predecir los resultados de los pacientes.

Objetivo del estudio:

Investigar el ALF en pacientes con epilepsia recién diagnosticada (NDE).; Determinar si el ALF está presente en el momento del diagnóstico de la epilepsia.; Evaluar la necesidad de una evaluación neuropsicológica temprana.

Principales métodos:

Estudio multicéntrico controlado por cohortes.; 22 pacientes con NDE y 25 controles sanos.; Pruebas de memoria en intervalos inmediatos, de 30 minutos y de cuatro semanas.

Principales resultados:

Los pacientes con NDE mostraron un olvido acelerado en tareas de recuerdo de historias.; El rendimiento en la tarea de pares asociados fue menor en NDE en todos los puntos de tiempo.; No se observaron diferencias significativas entre grupos en las pruebas de memoria visual y reconocimiento.

Conclusiones:

El ALF es una característica cognitiva presente en la epilepsia recién diagnosticada.; La cronicidad de la epilepsia no es la única causa del ALF.; Se recomienda la evaluación neuropsicológica temprana de rutina para los pacientes con NDE.

Palabras clave:

Cognición Epilepsia Memoria Epilepsia recién diagnosticada

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