Video Experimental Relacionado

Updated: Feb 20, 2026

Detection of Disease-associated α-synuclein by Enhanced ELISA in the Brain of Transgenic Mice Overexpressing Human A53T Mutated α-synuclein

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Published on: May 30, 2015

Detección de la actividad de siembra de alfa-sinucleína en el líquido lagrimal en pacientes con enfermedad de

Sezgi Canaslan¹, Matthias Schmitz², Fabian Maass¹

¹Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.

NPJ Parkinson's disease

|February 18, 2026

Abstract:

Detection of alpha-synuclein (α-Syn) seeding activity in tear fluid (TF) offers a promising non-invasive biomarker for Parkinson's disease (PD). α-Syn seeding amplification assay (αSynSAA) detected seeding activity in 67% of PD-TF, while non-synucleinopathy samples remained negative. Electron microscopy of seeding-positive end products revealed fibrillar structures morphologically consistent with results of αSynSAA. αSynSAA effectively distinguished PD from controls and prion diseases based on seeding activity in TF.

Palabras clave:

Neurociencia Descubrimiento de biomarcadores Oftalmología

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