Desarrollo y validación de un gráfico de corte para predecir la disfunción hepática posoperatoria tras la fijación con PFNA: punto final compuesto y análisis basado en Boruta
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Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure
Published on: August 14, 2017
Zhu Zhu1,2, Linbing Lou1, Luqi Yuan1
1Department of Orthopedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, 98 Nantong Road, Yangzhou, 225001, Jiangsu, People's Republic of China.
Background:
Postoperative liver dysfunction (PLD) is a notable complication following the fixation of intertrochanteric femoral fractures (ITFs) via proximal femoral nail antirotation (PFNA). Beyond increasing patient morbidity and mortality, this condition is also strongly associated with heightened healthcare expenditures. Nevertheless, there remains a lack of a practical, validated predictive model designed specifically for this surgical population. The present study thus seeks to develop and validate a user-friendly nomogram for the early prediction of PLD in ITF patients undergoing PFNA.
Methods:
A single-center retrospective analysis included 390 ITF patients who underwent PFNA between January 2022 and January 2025, selected via predefined inclusion/exclusion criteria. PLD was defined as an albumin-bilirubin (ALBI) score > -2.61 plus a neutrophil-to-lymphocyte ratio (NLR) ≥ 4. Demographic and laboratory data were collected. The Boruta algorithm identified key predictors; a multivariable logistic regression model was built and visualized as a nomogram. Model performance was assessed via receiver operating characteristic (ROC) analysis, calibration curves, and decision curve analysis (DCA), with internal validation using 1000 bootstrap resamples.
Results:
The final model incorporated 7 predictors: preoperative inflammatory markers (NLR, platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR)), coagulation parameter (activated partial thromboplastin time (APTT)), hematological indicators (hemoglobin, red blood cell count), and Evans fracture classification. Multivariable analysis identified independent PLD risk factors: preoperative APTT (OR = 1.05, p = 0.020), NLR ≥ 4 (OR = 3.90, p < 0.001), PLR > 300 (OR = 10.18, p = 0.026), and Evans Type IV fracture (OR = 3.49, p = 0.019). The nomogram showed strong discriminative power (AUC = 0.771, 95% CI 0.722-0.820), good calibration, a bias-corrected C-index of 0.720, and substantial clinical net benefits via DCA.
Conclusion:
A novel nomogram for predicting PLD in ITF patients after PFNA was successfully developed and internally validated. Using easily accessible clinical variables, this tool enables accurate early risk stratification, helping clinicians identify high-risk patients and optimize peri-operative care. It highlights the importance of inflammatory, coagulation, and fracture-related factors in PLD prediction for this cohort.
