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Updated: Feb 20, 2026

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Progreso de la investigación sobre el papel de DDR1 en el cáncer y la estrategia de terapia dirigida

Xiaoying Guan^1,2, Yajie Zhang³, Xiaoli Guan⁴

¹Pathology Department, The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, Gansu, China.

|February 19, 2026

Abstract:

Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase activated by various types of collagen. Abnormal activation of DDR1 is closely related to the occurrence and development of solid tumors and plays an important role in the regulation of cell adhesion, survival, proliferation, migration, and invasion. Thus, DDR1 is a promising therapeutic target in the field of oncology. This review introduces the structural characteristics of DDR1, focusing on its role in tumor progression and related signaling pathways. It also explores the relationship between DDR1 and tumor chemotherapy resistance, and elaborates on the current research status and development prospects for inhibitors and antibodies targeting DDR1. Thus, the DDR1 inhibition strategy may serve as a new alternative for treating cancer patients.

Palabras clave:

receptor 1 del dominio discoidina quinasa progresión tumoral quimiorresistencia terapia dirigida

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