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AraNSdb: una base de datos dedicada de ARN no codificantes que responden al estrés en Arabidopsis thaliana
A T Vivek1, Manika Bhatia1, Namrata Sahu1
1Bioinformatics Lab, National Institute of Plant Genome Research (NIPGR), Aruna Asaf Ali Marg, New Delhi, 110067 India.
3 Biotech
|February 19, 2026
Resumen
Una nueva base de datos, AraNSdb, cataloga más de 6.600 ARN no codificantes (ARNnc) que responden al estrés en Arabidopsis thaliana. Este recurso ayuda a investigar cómo las plantas responden a los desafíos ambientales utilizando la regulación de ARNnc.
Área de la Ciencia:
- Biología vegetal
- Genómica
- Biología molecular
Sus antecedentes:
- Las plantas se enfrentan a constantes estreses bióticos y abióticos, lo que requiere mecanismos de supervivencia robustos.
- Los ARN no codificantes (ARNnc) son reguladores críticos de las respuestas al estrés en las plantas.
- Anteriormente no existía un recurso centralizado para los ARN no codificantes que responden al estrés (SRN) en Arabidopsis thaliana.
Objetivo del estudio:
- Crear una base de datos completa de SRN en Arabidopsis thaliana.
- Proporcionar un recurso sistemático para consultar y analizar SRN.
- Facilitar la investigación sobre las respuestas al estrés mediadas por ARNnc.
Principales métodos:
- Se integraron datos de secuenciación de alto rendimiento y se extrajeron estudios publicados.
- Se construyó la base de datos de ARN no codificantes de Arabidopsis que responden al estrés (AraNSdb).
- Se incluyeron diversos tipos de SRN: miRNA, siRNA, lncRNA y circRNA.
Principales resultados:
- AraNSdb documenta más de 1.000 perfiles de expresión de diversos conjuntos de datos de estrés.
- La base de datos contiene 6.616 SRN identificados en Arabidopsis thaliana.
- Incluye una interfaz web intuitiva para explorar SRN y sus anotaciones.
Conclusiones:
- AraNSdb es un recurso valioso para estudiar las respuestas al estrés en las plantas.
- La base de datos apoya las investigaciones funcionales y regulatorias de los ARNnc.
- Mejora la comprensión de la adaptación mediada por ARNnc a las tensiones ambientales.
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