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Análisis de la Forma de Onda del Coágulo: ¿una herramienta potencial en la evaluación de la trombosis venosa?

Balkis Trabelsi, Hela Baccouche, Aya Chakroun

Annales de biologie clinique

|February 19, 2026

Resumen

El Análisis de la Forma de Onda del Coágulo (CWA) muestra potencial para detectar la hipercoagulabilidad en pacientes con trombosis venosa. Sin embargo, la baja sensibilidad limita su uso como herramienta de cribado universal para afecciones trombóticas.

Área de la Ciencia:

Hematología
Investigación de Trombosis
Hemostasia Diagnóstica

Sus antecedentes:

El Análisis de la Forma de Onda del Coágulo (CWA) está poco estudiado en condiciones trombóticas.
La hipercoagulabilidad es un factor clave en la trombosis venosa.
La evaluación de nuevos marcadores diagnósticos para la trombosis es crucial.

Objetivo del estudio:

Evaluar la eficacia de los parámetros de Análisis de la Forma de Onda del Coágulo (CWA) para identificar la hipercoagulabilidad asociada con la trombosis venosa.
Comparar el rendimiento de diferentes reactivos en CWA para la detección de trombosis.

Principales métodos:

Un estudio de casos y controles que involucró a 50 pacientes con trombosis venosa y 100 controles sanos.
Análisis de los parámetros de Análisis de la Forma de Onda del Coágulo (CWA) (Max1, Max2, Min2) utilizando reactivos de tiempo de tromboplastina parcial activada (aPTT) y tiempo de protrombina (PT) en un analizador ACL TOP 350.
Análisis de la curva ROC (Receiver Operating Characteristic) para determinar el rendimiento diagnóstico.

Principales resultados:

Los parámetros de CWA fueron significativamente más altos en pacientes con trombosis venosa en comparación con los controles en los reactivos probados.
Los parámetros específicos de CWA demostraron grados variables de sensibilidad y especificidad, y algunos umbrales no fueron discriminatorios.
El reactivo SynthASil mostró un mayor potencial diagnóstico para ciertos parámetros de CWA en comparación con SynthAFax y RecombiPlasTin.

Conclusiones:

Los parámetros de Análisis de la Forma de Onda del Coágulo (CWA) pueden indicar hipercoagulabilidad en la trombosis venosa.
La utilidad diagnóstica de CWA para la trombosis venosa depende del reactivo.
La baja sensibilidad de los parámetros actuales de CWA restringe su aplicación como prueba de cribado independiente para la hipercoagulabilidad en la trombosis.

Palabras clave:

hematología hemostasia hipercoagulabilidad trombosis venosa

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