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Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
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Respuesta a "comentario sobre: Microcarcinomas papilares multifocales de tiroides: ¿se asocia el diámetro total del

Larissa Ariane de Nardi1, Ana Flávia Aguiar Ribeiro Coutinho1, Carlos Segundo Paiva Soares2

  • 1Internal Medicine Department, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista "Júlio de Mesquita Filho", Botucatu, SP, Brazil.

Einstein (Sao Paulo, Brazil)
|February 19, 2026
PubMed
Resumen

No abstract available in PubMed .

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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