Estimación de las tasas de complicaciones postoperatorias en pacientes con tumores cerebrales primarios a partir de...

Neurosurgery is an important element of brain tumour treatment but carries with it the risk of complications. Previous work has defined a narrow set of general post-operative complications which are used as Patient Safety Indicators (PSIs), but these are not brain tumour specific and do not capture the full range of complications. As a result, there is no way of measuring post-operative complications in neurosurgery at a national level.

We conducted a retrospective, observational cohort study using a comprehensive national administrative dataset from England on adult brain or spinal tumour patients to better define post-operative complications. We generated and validated a new list of post-operative complications - ICL list. The ICL list contains codes selected specifically from our Gliocova dataset combined with general OECD-defined PSI list. The ICL list is novel as it can assess brain tumour patient complications using an administrative dataset at a national level and captures more specific brain tumour related complications.

In our study, 30-day readmission after surgery was 12.7% and 30-day mortality was 2.3%. The ICL list of complications identified many more patients with complications (N = 3,274 (11.3%)) compared to OECD-defined PSI list (N = 568 (2.0%)) without reducing model performance. 30-day mortality was 6.5% in those with complications and 1.8% in those without.

We have identified a much wider set of complications than the OECD-defined PSIs and shown that patients developing these have worse outcomes than those without complications. This enables us to estimate the risk of post-operative complications in brain tumour patients using national administrative data. It forms the basis for planned further work, allowing us to explore the predictors of and consequences of post-operative complications.