Video Experimental Relacionado

Updated: Jun 20, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

Control selectivo de la unión de ligandos a través de una mutación distal que altera el ensamble nativo de la

Rahul Dani1, Iladeiti Kurbah2, Dhruv Kumar Chaurasiya1

  • 1Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, India.

Proceedings of the National Academy of Sciences of the United States of America
|February 19, 2026
PubMed
Resumen

Una mutación W86A en un dominio de unión de acil-CoA causa el desplegamiento de la proteína y una conformación alternativa, afectando la unión del ligando. Este estudio revela cómo las mutaciones distantes afectan la función de la proteína a través de dinámicas y termodinámicas alteradas.

Palabras clave:
dinámicarelación plegamiento-funciónmutacionesestabilidadtermodinámica

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