Video Experimental Relacionado

Updated: May 5, 2026

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

Nanopartículas de 8-shogaol/curcumina autoensambladas mediante enlaces de hidrógeno: estabilidad mejorada y

Rui Zhang¹, Jing-Yu Feng¹, Kiran Thakur²

¹School of Food and Biological Engineering, Hefei University of Technology, Hefei 230601, China.

|February 19, 2026

Abstract:

This study synthesized curcumin/polyvinyl pyrrolidone (PVP)/8-shogaol nanoparticles (PCS-NPs) loaded with 8-shogaol using hydrogen bonding self-assembly. Firstly, transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), ¹H NMR spectrometer and other techniques were used to characterize the size and molecular structure of PCS-NPs. The optimized PCS-NPs exhibited a particle size of 82.58 nm, a zeta potential of -22.4 mV, an encapsulation efficiency of 81.4%, and a loading capacity rate of 15.08%. Molecular dynamics simulations elucidated the mode of hydrogen bonding interactions within the PCS-NPs. Stability analysis revealed that PCS-NPs possessed superior storage stability and demonstrated remarkable stability under temperature and UV irradiation conditions. PCS-NPs exerted higher release efficiency in the intestine as well as higher intestinal transport efficiency. This study laid the theoretical foundation for enhancing the solubility, stability, and bioaccessibility of 8-Shogaol.

Palabras clave:

8-shogaol Biodisponibilidad Modelo de transporte transepitelial Caco-2 Curcumina Enlaces de hidrógeno Simulaciones de dinámica molecular Estabilidad

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