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Quimeras dirigidas a lisosomas para la degradación de proteínas dirigida

Bozhao Li1, Yanyan Li2, Jian Zhang3

  • 1Institutes of Biomedical Sciences, Inner Mongolia University, Hohhot 010070, China; Institute of Nanotechnology and Intelligence (inAI), Jinan University, Guangzhou 510632, China.

Cell chemical biology
|February 19, 2026
PubMed
Resumen

Las quimeras dirigidas a lisosomas (LYTACs) ofrecen una nueva forma de degradar proteínas extracelulares para beneficio terapéutico. Esta revisión detalla los mecanismos de LYTAC, la participación de receptores y los desafíos para el desarrollo de fármacos de próxima generación.

Palabras clave:
LYTACsdegradación de proteínas extracelularesquimeras dirigidas a lisosomasendocitosis mediada por receptoresdegradación de proteínas dirigida

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