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Updated: Aug 17, 2026

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AARS1-dependent lactilación dirigida mejora la plasticidad de los procesos neuronales y mitiga los déficits

Shiyuan Luo1, Zhuochen Lyu1, Hongjun Huang1

  • 1Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Brain, behavior, and immunity
|February 19, 2026
PubMed
Resumen

La acumulación de lactato en la encefalopatía asociada a la sepsis (EAS) daña las neuronas a través de la lactilación de ATRIP mediada por AARS1. La L-alanina o la inhibición de ATR restauran la función cognitiva en modelos de ratón con EAS, ofreciendo posibles dianas terapéuticas.

Palabras clave:
encefalopatía asociada a la sepsislactatolactilaciónAARS1ATRIPATRneuroinflamaciónplasticidad neuronaldéficits cognitivosterapias dirigidas

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