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Activación selectiva de PPAR δ y eficacia de Seladelpar en la colangitis biliar primaria y más allá

Alessio Gerussi¹, Matteo Fornai²

¹Centre for Autoimmune Liver Diseases, Division of Gastroenterology, Fondazione IRCCS San Gerardo dei Tintori, ERN-RARE LIVER Center, Monza, Italy; Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

Pharmacological research

|February 19, 2026

Abstract:

Seladelpar is a selective PPAR-δ agonist approved for the treatment of the rare cholestatic disease Primary Biliary Cholangitis, in patients who do not achieve adequate biochemical control with first-line therapy. This review outlines the characteristics of PPAR-δ, with insights into its activity across different tissues, and summarizes the pharmacology of Seladelpar, providing the background for the subsequent discussion of its clinical efficacy and safety in humans.

Palabras clave:

Mecanismo de acción Agonista de PPARδ Colangitis biliar primaria Seladelpar

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