Search research articles

ACERCA DE JoVE

Visión General Liderazgo Blog Centro de Ayuda JoVE

AUTORES

Proceso de Publicación Consejo Editorial Alcance y Políticas Revisión por Pares Preguntas Frecuentes Enviar

BIBLIOTECARIOS

Testimonios Suscripciones Acceso Recursos Consejo Asesor de Bibliotecas Preguntas Frecuentes

INVESTIGACIÓN

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archivo

EDUCACIÓN

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Centro de Recursos para Profesores Sitio de Profesores

Términos y Condiciones de Uso

Política de Privacidad

Videos de Conceptos Relacionados

Porin Insertion in the Outer Mitochondrial Membrane

Porin Insertion in the Outer Mitochondrial Membrane

Porins are beta-barrel proteins translocated to the mitochondrial outer membrane through the TOM complex into the intermembrane space. Porin precursors bind TIM chaperones within the intermembrane space and are guided to the Sorting and Assembly Machinery complex or SAM complex on the outer mitochondrial membrane.
Three models describe the assembly of porins by the SAM complex and their insertion into the outer membrane. Model 1 suggests that porins are assembled outside the SAM channel as the...

pV-Diagrams

pV-Diagrams

The pV diagram, which is a graph of pressure versus volume of the gas under study, is helpful in describing certain aspects of the substance. When the substance behaves like an ideal gas, the ideal gas equation describes the relationship between its pressure and volume. On a pV diagram, it is common to plot an isotherm, which is a curve showing p as a function of V with the number of molecules and the temperature fixed. Then, for an ideal gas, the product of the pressure of the gas and its...

Fluid Pressure over Curved Plate of Constant Width

Fluid Pressure over Curved Plate of Constant Width

When a curved plate of constant width is submerged in a liquid, the pressure acting normal to the plate varies continuously both in magnitude and direction. Calculating the magnitude and location of the resultant force at a point is often challenging for such cases. One of the methods to determine the resultant force and its location involves separately calculating the horizontal and vertical components of the resultant force. This complex calculation can be simplified by representing the...

Fluid Pressure over Flat Plate of Variable Width

Fluid Pressure over Flat Plate of Variable Width

When a flat plate is submerged in a fluid, the fluid exerts pressure on the plate. This pressure can lead to many different phenomena, including drag and buoyancy. To understand the behavior of the fluid over a flat plate of variable width, it is essential to analyze the distribution of the pressure exerted.
The pressure distribution on the plate can be calculated by determining the force that acts on a differential area strip of the plate. Thus, the magnitude of the force is equal to the...

Structure and Function of Platelets

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...

Formation of the Platelet Plug

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por

Same author

Correction: Fahmy et al. Palladium Nanoparticles Fabricated by Green Chemistry: Promising Chemotherapeutic, Antioxidant and Antimicrobial Agents. <i>Materials</i> 2020, <i>13</i>, 3661.

Materials (Basel, Switzerland)·2026

Same author

Correction: Fahmy et al. PEGylated Chitosan Nanoparticles Encapsulating Ascorbic Acid and Oxaliplatin Exhibit Dramatic Apoptotic Effects against Breast Cancer Cells. <i>Pharmaceutics</i> 2022, <i>14</i>, 407.

Pharmaceutics·2026

Same author

Nanoencapsulation of <i>Rhodiola rosea</i> extract into 2-hydroxypropyl-β-cyclodextrin: enhanced antibacterial and anticancer activities.

RSC advances·2026

Same author

Enhanced cytotoxic activity of <i>Moringa oleifera</i>-loaded pharmacosomes against neuroblastoma.

Nanoscale advances·2026

Same authorSame journal

Rosuvastatin calcium: A comprehensive profile.

Profiles of drug substances, excipients, and related methodology·2026

Same author

<i>Saussurea costus</i> in nanomedicine: green-synthesized metal nanoparticles and advanced nanosystems for enhanced therapeutic efficacy.

RSC advances·2026

Same journal

Preface.

Profiles of drug substances, excipients, and related methodology·2026

Same journal

Kinetic exclusion assay technology: Theory, experimental aspects, and applications in concentration measurements across diverse fields.

Profiles of drug substances, excipients, and related methodology·2026

Same journal

Drugs and polymer based local delivery systems in the treatment of periodontal diseases.

Profiles of drug substances, excipients, and related methodology·2026

Same journal

Ferulic acid: A comprehensive profile.

Profiles of drug substances, excipients, and related methodology·2026

Same journal

Vortioxetine: A comprehensive profile.

Profiles of drug substances, excipients, and related methodology·2026

Ver todos los artículos relacionados

Search research articles

Video Experimental Relacionado

Updated: Jun 6, 2026

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles

Published on: August 16, 2012

Perindopril: Un perfil completo

Jude Majed Lababidi¹, Mohamed Fawzy Kabil¹, Hassan Mohamed El-Said Azzazy¹

¹Department of Chemistry, School of Sciences and Engineering, The American University in Cairo, New Cairo, Egypt.

Profiles of drug substances, excipients, and related methodology

|February 19, 2026

Resumen

Este resumen es generado por máquina.

Este capítulo detalla las propiedades de la arginina de perindopril (PER-Arg) y los métodos analíticos para cuantificarla y la erbumina de perindopril (PER-E). Cubre atributos fisicoquímicos, síntesis y diversas técnicas de cuantificación para estos inhibidores de la ECA.

Palabras clave:

Inhibidor de la enzima convertidora de angiotensina (ECA)Cromatografía Resonancia magnética nuclear Perindopril Espectrofluorometría Espectrofotometría Análisis térmico Espectro UV

Más Videos Relacionados

PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions

PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions

Published on: July 27, 2017

Platelet-Rich Plasma Lysate for Treatment of Eye Surface Diseases

Platelet-Rich Plasma Lysate for Treatment of Eye Surface Diseases

Published on: August 2, 2022

Videos de Experimentos Relacionados

Last Updated: Jun 6, 2026

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles

Published on: August 16, 2012

PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions

PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions

Published on: July 27, 2017

Platelet-Rich Plasma Lysate for Treatment of Eye Surface Diseases

Platelet-Rich Plasma Lysate for Treatment of Eye Surface Diseases

Published on: August 2, 2022

Área de la Ciencia:

Química Farmacéutica
Química Analítica

Sus antecedentes:

El perindopril (PER) es un inhibidor de la enzima convertidora de angiotensina (ECA) utilizado para la hipertensión y las enfermedades cardiovasculares.
Se han desarrollado dos sales principales, arginina de perindopril (PER-Arg) y erbumina de perindopril (PER-E).

Objetivo del estudio:

Proporcionar una visión general completa de las propiedades fisicoquímicas de PER-Arg.
Discutir las metodologías analíticas para cuantificar PER-Arg y PER-E.

Principales métodos:

Caracterización fisicoquímica de PER-Arg (estructura, síntesis, cristalografía, estabilidad térmica, absorbancia UV).
Revisión de métodos de cuantificación que incluyen cromatografía, espectrofotometría, espectrofluorimetría, biosensores e inmunoensayo radioactivo.

Principales resultados:

Se estableció el perfil fisicoquímico detallado de PER-Arg.
Se discutieron varias técnicas analíticas adecuadas para cuantificar PER-Arg y PER-E en diversas matrices.

Conclusiones:

La comprensión de las propiedades de PER-Arg es crucial para su aplicación farmacéutica.
Existe una gama de métodos analíticos validados para la cuantificación precisa de PER-Arg y PER-E.