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Perindopril: Un perfil completo

Jude Majed Lababidi¹, Mohamed Fawzy Kabil¹, Hassan Mohamed El-Said Azzazy¹

¹Department of Chemistry, School of Sciences and Engineering, The American University in Cairo, New Cairo, Egypt.

Profiles of drug substances, excipients, and related methodology

|February 19, 2026

Resumen

Este capítulo detalla las propiedades de la arginina de perindopril (PER-Arg) y los métodos analíticos para cuantificarla y la erbumina de perindopril (PER-E). Cubre atributos fisicoquímicos, síntesis y diversas técnicas de cuantificación para estos inhibidores de la ECA.

Área de la Ciencia:

Química Farmacéutica
Química Analítica

Sus antecedentes:

El perindopril (PER) es un inhibidor de la enzima convertidora de angiotensina (ECA) utilizado para la hipertensión y las enfermedades cardiovasculares.
Se han desarrollado dos sales principales, arginina de perindopril (PER-Arg) y erbumina de perindopril (PER-E).

Objetivo del estudio:

Proporcionar una visión general completa de las propiedades fisicoquímicas de PER-Arg.
Discutir las metodologías analíticas para cuantificar PER-Arg y PER-E.

Principales métodos:

Caracterización fisicoquímica de PER-Arg (estructura, síntesis, cristalografía, estabilidad térmica, absorbancia UV).
Revisión de métodos de cuantificación que incluyen cromatografía, espectrofotometría, espectrofluorimetría, biosensores e inmunoensayo radioactivo.

Principales resultados:

Se estableció el perfil fisicoquímico detallado de PER-Arg.
Se discutieron varias técnicas analíticas adecuadas para cuantificar PER-Arg y PER-E en diversas matrices.

Conclusiones:

La comprensión de las propiedades de PER-Arg es crucial para su aplicación farmacéutica.
Existe una gama de métodos analíticos validados para la cuantificación precisa de PER-Arg y PER-E.

Palabras clave:

Inhibidor de la enzima convertidora de angiotensina (ECA)Cromatografía Resonancia magnética nuclear Perindopril Espectrofluorometría Espectrofotometría Análisis térmico Espectro UV

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