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Amany A Aboomeirah1, Ahmed Maher Abdeldayem1, Hassan Mohamed El-Said Azzazy1

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La rosuvastatina cálcica es un fármaco estatina que reduce eficazmente el colesterol alto cuando los cambios en el estilo de vida son insuficientes. Esta revisión detalla sus propiedades, síntesis, análisis térmico y métodos analíticos para el control de calidad.

Palabras clave:
HPLCInhibidor de la hidroximetilglutaril-CoA (HMG-CoA) reductasaRMNFarmacocinéticaRosuvastatina cálcicaAnálisis térmicoEspectroscopía UV

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Sus antecedentes:

  • El manejo de la hipercolesterolemia a menudo requiere intervención farmacológica cuando las modificaciones del estilo de vida fallan.
  • La rosuvastatina cálcica (Ros-Ca) representa un desarrollo significativo en la clase de fármacos estatinas para la reducción del colesterol.
  • Los factores genéticos y otras condiciones de salud pueden requerir tratamiento farmacológico para el colesterol alto.

Objetivo del estudio:

  • Proporcionar una revisión exhaustiva de la rosuvastatina cálcica.
  • Detallar las características fisicoquímicas, la síntesis y el análisis térmico de Ros-Ca.
  • Explorar metodologías analíticas para la evaluación cuantitativa y cualitativa de Ros-Ca.

Principales métodos:

  • Revisión de la literatura sobre rosuvastatina cálcica.
  • Análisis de propiedades fisicoquímicas.
  • Examen de las vías de síntesis.
  • Revisión de las técnicas de análisis térmico.
  • Encuesta de métodos analíticos para la cuantificación e identificación de Ros-Ca.

Principales resultados:

  • La rosuvastatina cálcica inhibe eficazmente la síntesis hepática de colesterol.
  • Se presentan datos fisicoquímicos, de síntesis y térmicos detallados.
  • Una gama de técnicas analíticas son adecuadas para el análisis de Ros-Ca.

Conclusiones:

  • La rosuvastatina cálcica es un agente terapéutico clave para el manejo de la hipercolesterolemia.
  • La comprensión de sus características y métodos analíticos es crucial para el aseguramiento de la calidad.
  • Esta revisión sirve como un recurso valioso para investigadores y profesionales farmacéuticos.