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Xiaodi Liu1, Yingnan Liu2,3, Mong Li Lee2,3
1Institute of Data Science, National University of Singapore, Singapore, Singapore. idsv33@visitor.nus.edu.sg.
NPJ digital medicine
|February 19, 2026
Abstract:
This reply addresses Wang et al.'s comments on our prior work and clarifies that the 34.5-point Knee Society Score threshold was derived from our previously validated, anchor-based approach. We agree that future research should refine predictive models by establishing consensus, standardised minimal clinically important difference cutoffs to enhance applicability and reliability in real-world clinical settings.
