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Estudio transversal del transporte de patógenos prioritarios resistentes en el entorno hospitalario en Timor-Leste
Sarah A Lynar1,2,3, A Vieira4, A D K Draper4,5,6
1Menzies School of Health Research, Charles Darwin University, Dili, Timor-Leste. sarah.lynar@nt.gov.au.
Antimicrobial resistance and infection control
|February 20, 2026
Resumen
La resistencia a los antimicrobianos es una amenaza global. Se encontraron altas tasas de resistencia a ESBL, ciprofloxacina y gentamicina en Timor-Leste, mientras que la resistencia a MRSA y carbapenem era baja, lo que requería una vigilancia continua.
Área de la Ciencia:
- Microbiología Microbiología.
- Salud Pública La salud pública.
- Enfermedades infecciosas Enfermedades infecciosas.
Sus antecedentes:
- La resistencia a los antimicrobianos (AMR) plantea un desafío significativo para la salud mundial.
- La Organización Mundial de la Salud (OMS) identifica los patógenos críticos de la resistencia antimicrobiana a través del Sistema Mundial de Vigilancia de la Resistencia y el Uso de Antimicrobianos (GLASS).
- Timor-Leste ha mejorado sus capacidades de diagnóstico, lo que permite la vigilancia de la resistencia antimicrobiana.
Objetivo del estudio:
- Realizar un estudio de vigilancia transversal de la resistencia a los antimicrobianos en pacientes internados y ambulatorios en Timor-Leste.
- Determinar la prevalencia de los principales organismos resistentes, incluidos el Staphylococcus aureus (MRSA) y la beta-lactamasa de espectro extendido (ESBL) que producen bacterias Gram-negativas.
- Para evaluar las asociaciones entre la resistencia y los factores demográficos o ambientales.
Principales métodos:
- Se realizó un estudio transversal en 2020-2021 en todos los hospitales de Timor-Leste.
- Los hisopos se cultivaron para S. aureus (incluido MRSA) y organismos productores de ESBL.
- Se analizaron los aislados de S. aureus, Escherichia coli y Klebsiella pneumoniae para determinar la resistencia a la ciprofloxacina y la gentamicina; se realizaron análisis univariados y multivariados.
Principales resultados:
- La prevalencia de S. aureus fue del 18,0% (MRSA 2,7%).
- La prevalencia de los organismos productores de ESBL fue del 21,1%, con una resistencia al ciprofloxacino del 21,3% y una resistencia a la gentamicina del 15,1%.
- Se observaron tasas más altas de resistencia a ESBL, ciprofloxacina y gentamicina en Dili; el estado de paciente hospitalizado estaba vinculado a la resistencia a la gentamicina; la propiedad de perros al transporte de ESBL.
Conclusiones:
- Las tasas de transporte de la ESBL, la ciprofloxacina y la resistencia a la gentamicina fueron altas, especialmente en Dili.
- El transporte de S. aureus resistente a la meticilina (MRSA) y la resistencia al carbapenem fueron bajos.
- La vigilancia continua de la resistencia antimicrobiana es crucial para monitorear las tendencias y orientar las pautas de tratamiento.
Palabras clave:
Propiedad de animales Propiedad de animales.La resistencia a los antimicrobianos.Los organismos de GLASS se encuentran en los organismos de GLASS.La vigilancia pasiva es la vigilancia pasiva.Timor-Leste es una región de Timor Oriental.Los entornos urbanos Los entornos urbanos son entornos urbanos en los que se encuentra el entorno urbano.Más Videos Relacionados
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