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Explorando la osteosarcopenia desde la perspectiva de la microbiota intestinal: conocimientos mecanicistas y
Hao-Bo Jiang1,2, Jun-Qi Zhang2, Hao Liang2
1Department of Orthopedics, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
Frontiers in microbiology
|February 20, 2026
Resumen
La osteosarcopenia (OS), el deterioro del hueso y el músculo en el envejecimiento, está relacionado con el desequilibrio de la microbiota intestinal (GM). Dirigirse a los transgénicos a través de la dieta, los probióticos o la FMT puede ofrecer nuevas vías terapéuticas para esta condición.
Área de la Ciencia:
- Gerontología y Salud Musculoesquelética.
- Investigación del microbioma Investigación del microbioma.
- Las vías metabólicas e inflamatorias.
Sus antecedentes:
- La osteosarcopenia (OS) implica pérdida simultánea de hueso y músculo, aumentando los riesgos de fractura, discapacidad y mortalidad.
- La microbiota intestinal (GM) es cada vez más reconocida por su papel en la regulación de la salud ósea y muscular.
- Comprender el eje intestino-músculo-hueso es crucial para abordar la patogénesis de la OS.
Objetivo del estudio:
- Revisar e integrar la evidencia sobre el eje intestino-músculo-hueso en la osteosarcopenia.
- Aclarar los mecanismos por los cuales la disbiosis GM contribuye a la OS.
- Explorar posibles estrategias terapéuticas dirigidas a los transgénicos para la OS.
Principales métodos:
- Revisión sistemática de la literatura actual sobre la microbiota intestinal, la salud ósea y la salud muscular.
- Integración de la evidencia de la osteoporosis, la sarcopenia y los estudios mecanicistas.
- Desarrollo del marco conceptual para el eje intestino-músculo-hueso en la OS.
Principales resultados:
- La disbiosis transgénica puede conducir el sistema operativo a través de la barrera intestinal deteriorada, la inflamación crónica y la absorción alterada de nutrientes.
- Los metabolitos GM (por ejemplo, SCFAs) y la inflamación sistémica impactan las células óseas y musculares.
- La señalización bidireccional a través de miokinas y osteokinas regula la homeostasis musculoesquelética.
Conclusiones:
- El eje intestino-músculo-hueso proporciona un marco para comprender la patogénesis de la OS.
- Las intervenciones centradas en la microbiota (dieta, probióticos, FMT) son prometedoras para la OS.
- Se necesita más investigación clínica para validar las terapias dirigidas a los transgénicos para la osteosarcopenia.
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