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Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
Published on: January 7, 2014
Tendencias de investigación sobre neuroinflamación en la enfermedad de Parkinson: un análisis exploratorio
Yan-Jun Chen1,2, Ming-Rong Xie3, Fang Liu4
1The First Hospital of Hunan University of Chinese Medicine, Changsha, China.
Frontiers in aging neuroscience
|February 20, 2026
Resumen
La investigación sobre la neuroinflamación en la enfermedad de Parkinson (EP) está creciendo. Las áreas clave incluyen la microglía, el estrés oxidativo y la microbiota intestinal, lo que indica un avance hacia una comprensión mecanicista más profunda.
Área de la Ciencia:
- Neurociencia
- Inmunología
- Bibliometría
Sus antecedentes:
- La neuroinflamación es un factor clave en la patogénesis de la enfermedad de Parkinson (EP).
- El interés en la investigación sobre la EP y la neuroinflamación se está expandiendo rápidamente.
- Comprender estos vínculos es crucial para desarrollar nuevas estrategias terapéuticas.
Objetivo del estudio:
- Analizar el panorama actual de la investigación sobre neuroinflamación en la EP.
- Identificar los puntos clave de investigación y las publicaciones influyentes.
- Explorar las tendencias emergentes y las direcciones futuras de la investigación.
Principales métodos:
- Análisis bibliométrico de publicaciones de Web of Science y PubMed.
- Se utilizaron CiteSpace, VOSviewer y el paquete R bibliometrix para el análisis de datos y la visualización.
- Se identificaron tendencias de publicación, instituciones influyentes, revistas y autores.
Principales resultados:
- Se observó una tendencia ascendente significativa en las publicaciones sobre neuroinflamación en la EP.
- China lideró en volumen de publicaciones, mientras que Noruega mostró la mayor influencia.
- Los términos clave de investigación incluyeron EP, neuroinflamación, microglía, estrés oxidativo y alfa-sinucleína; la microbiota intestinal emergió como un foco reciente.
Conclusiones:
- La investigación sobre neuroinflamación en la EP ha mostrado un crecimiento continuo durante dos décadas.
- Los puntos clave incluyen la microglía, el estrés oxidativo, la alfa-sinucleína y el eje intestino-cerebro.
- El campo está evolucionando hacia una exploración multidimensional y en profundidad de los mecanismos.
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