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Displasias convencionales y no convencionales asociadas con enfermedad inflamatoria intestinal-Una experiencia de un
Anita Sejben1, Zsófia Balajthy1, Zsófia Krisztina Török1
1Department of Pathology, University of Szeged, 6725 Szeged, Hungary.
Medical sciences (Basel, Switzerland)
|February 20, 2026
Resumen
La displasia no convencional ocurre en el 28% de los pacientes con enfermedad inflamatoria intestinal (EII) con lesiones neoplásicas. La evaluación histopatológica mejorada y la vigilancia intensificada son cruciales para el manejo de la displasia asociada a la EII.
Área de la Ciencia:
- Gastroenterología y Gastroenterología.
- Patología Patología Patología.
- Oncología Oncología.
Sus antecedentes:
- La enfermedad inflamatoria intestinal (EII) se asocia con un mayor riesgo de cáncer colorrectal.
- Investigaciones recientes han identificado varias lesiones displásicas no convencionales en pacientes con EII.
- La caracterización de estas lesiones es esencial para la estratificación y gestión del riesgo.
Objetivo del estudio:
- Caracterizar y comparar las displasias convencionales y no convencionales en pacientes con EII.
- Determinar la prevalencia de estas displasias en una población del sur de Hungría.
- Para identificar los factores asociados con el desarrollo de la displasia asociada a la EII.
Principales métodos:
- Análisis retrospectivo de una cohorte consecutiva de pacientes con EII (2011-2023).
- Reclasificación de muestras hiperplásticas o neoplásicas de acuerdo con los criterios patológicos actuales.
- Análisis estadístico para identificar asociaciones entre las características del paciente y los subtipos de displasia.
Principales resultados:
- De 176 pacientes con EII con muestras evaluables, el 74% tenía displasia convencional y el 28% tenía displasia no convencional.
- La edad avanzada y el género masculino se asociaron con mayores probabilidades de displasia convencional.
- El desarrollo de carcinoma colorrectal y la etapa avanzada de M se asociaron con probabilidades más bajas de displasia convencional.
Conclusiones:
- Las displasias no convencionales representan una proporción significativa (28%) de las lesiones neoplásicas en pacientes con EII.
- Una evaluación histopatológica exhaustiva es fundamental para confirmar la resección completa de las lesiones displásicas.
- Las estrategias de vigilancia intensificada pueden beneficiar a los pacientes con EII con displasia, especialmente los tipos no convencionales.
Palabras clave:
La enfermedad de Crohn es la enfermedad de Crohn.Las neoplasias asociadas a la EII son neoplasias asociadas a la EII.enfermedad inflamatoria del intestino enfermedad inflamatoria del intestino.La displasia no convencional es una displasia no convencional.La colitis ulcerosa también se conoce como colitis ulcerosa.
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