Video Experimental Relacionado
Updated: Feb 22, 2026
10:16
High-throughput Antiviral Assays to Screen for Inhibitors of Zika Virus Replication
Published on: October 30, 2021
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La vitamina D reprograma las redes de ARN no codificantes para bloquear el virus Zika en macrófagos humanos
Julieta M Ramírez-Mejía1, Geysson Javier Fernandez1,2, Silvio Urcuqui-Inchima2
1Grupo Biología y Control de Enfermedades Infecciosas, Universidad de Antioquia UdeA, Medellín 050010, Colombia.
Resumen
La vitamina D modula las respuestas de los macrófagos al virus Zika (ZIKV) alterando las redes de ARN no codificantes y ARNm. Este estudio identifica moléculas y vías clave involucradas en la infección por ZIKV y la regulación inmunitaria.
Sus antecedentes:
- La infección por el virus Zika (ZIKV) presenta riesgos de malformaciones congénitas y trastornos neuroinflamatorios.
- Los macrófagos son objetivos y reservorios cruciales para el ZIKV, y median las respuestas antivirales y inflamatorias.
- La vitamina D (VitD) es un inmunomodulador que mejora la actividad antimicrobiana de los macrófagos y regula la inflamación.
Conclusiones:
- Este estudio proporciona un mapa exploratorio de las redes ncRNA-ARNm influenciadas por VitD durante la infección por ZIKV.
- Las moléculas y vías candidatas identificadas justifican una mayor investigación sobre las interacciones huésped-virus.
- Destaca el potencial de VitD para modular las respuestas de los macrófagos y la regulación inmunitaria contra el ZIKV.
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