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Updated: Feb 22, 2026

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Una chaperona Hsp70 está involucrada en el silenciamiento meiótico por ADN no apareado

Victor T Sy¹, Sterling S Trawick¹, Hagen M Tatarsky¹

¹Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA.

|February 20, 2026

Abstract:

In the filamentous fungus Neurospora crassa, a gene not having a pairing partner during meiosis is seen as a potential intruder and is targeted by a mechanism called meiotic silencing by unpaired DNA (MSUD). MSUD employs core RNA interference (RNAi) components such as the SMS-2 Argonaute, which uses small interfering RNAs (siRNAs) as guides to seek out mRNAs from unpaired genes for silencing. In Drosophila melanogaster, the heat shock protein 70 (Hsp70) chaperone system facilitates the conformational activation of an Argonaute and allows it to load siRNAs. Here, our results demonstrate that an Hsp70 protein in Neurospora interacts with SMS-2 and mediates the silencing of unpaired genes.

Palabras clave:

Neurospora crassa interferencia de ARN (ARNi)defensa genómica proteínas de choque térmico (HSPs)silenciamiento meiótico por ADN no apareado (MSUD)

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